• E Tabouret, F Fina, F Vincentelli, I Nanni, and D Figarella-Branger.
• APHM, Timone Hospital, Department of Anatomopathology, 13005 Marseille, France; Aix-Marseille Univ, CRO2, Inserm U911, 13005 Marseille, France. Electronic address: emeline.tabouret@gmail.com.
• J. Neurol. Sci. 2014 Jul 15;342(1-2):204-6.

BackgroundIDH mutations and BRAF mutations are classically mutually exclusive and usually associated with infiltrative or circumscribed gliomas and glioneuronal tumors respectively.Case ReportWe report the case of a 26-year old man with intracranial hypertension revealing voluminous right frontal lesion. Surgical resection was performed and pathological examination found two distinct tumoral areas: a glioma-like area with calcification without mitosis; a second with pleomorphic glial cells with higher Mib index, high CD34 expression and endothelial proliferation. No necrosis was recorded. Molecular analyses revealed both IDH1 I113T and BRAF V600E mutations. Although this glioma was difficult to clarify, diagnosis of pleomorphic xanthoastrocytoma with anaplastic feature was suggested based on the association of some pathological feature (eosinophilic granular bodies, reticulin network and diffuse CD34 expression) and the BRAF V600E mutation.ConclusionWe report a new IDH1 mutation associated with BRAF mutation in a very unusual glial tumor.Copyright © 2014 Elsevier B.V. All rights reserved.

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