• Oncol Lett · Nov 2010

    Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.

    • Xiao-Ming Xia, Wei-Yun Jin, Ren-Zhong Shi, Ya-Feng Zhang, and Jun Chen.
    • Department of Thoracic Surgery, Jinshan Branch of the Sixth People's Hospital, Affiliated with Shanghai Jiaotong University, Shanghai 201500, P.R. China.
    • Oncol Lett. 2010 Nov 1;1(6):1045-1047.

    AbstractTo detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate their significance, the expression of let-7 and K-ras was determined in cancerous tissues and pericancerous normal tissues of 31 NSCLC patients using reverse transcription-polymerase chain reaction. Our results using 31 NSCLC patient samples showed that 67.74% had a low let-7 expression (P<0.05), 64.52% had a high K-ras expression (P<0.05), and a significant correlation was observed between let-7 and K-ras gene expression (r=-0.6336) in tumor tissues. Patients with a low let-7 expression had a significantly shorter survival than those with a moderate let-7 expression (P<0.05). Patients with a high K-ras expression also had a significantly shorter survival than those with a moderate K-ras expression (P<0.05). In conclusion, a low expression of let-7 and a high expression of K-ras are correlated with the pathogenesis and prognosis of NSCLC.

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