• Minerva anestesiologica · Mar 2011

    Case Reports

    Therapeutic hypothermia for space-occupying Herpes simplex virus encephalitis.

    • I Wagner, D Staykov, B Volbers, S Kloska, A Dörfler, S Schwab, and J Bardutzky.
    • Department of Neurology, University Hospital of Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany. ingrid.wagner@uk-erlangen.de
    • Minerva Anestesiol. 2011 Mar 1;77(3):371-4.

    AbstractDevelopment of space-occupying edema in patients with severe Herpes simplex virus encephalitis is a major factor for high morbidity and mortality. Conventional intracranial pressure-lowering modalities are limited and more aggressive treatment options for such patients have rarely been described. This article reports on a HIV-positive patient with Herpes simplex type 2 encephalitis and elevated intracranial pressure refractory to medical therapy. Induced moderate hypothermia of 33 °C resulted in fast and sustained control of intracranial pressure. After three months, the patient had a fairly good functional outcome with a Glasgow Outcome Scale score of 4.

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