• Daniella Mancino da Luz Caixeta, Fernanda Moraes Daniel Fialho, Zina Maria Almeida Azevedo, Paulo Ferrez Collett-Solberg, Nivaldo Ribeiro Villela, and Eliete Bouskela.
• Instituto Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro/RJ, Brazil. daniellamancino@hotmail.com
• Clinics (Sao Paulo). 2013 Jul 1;68(7):1061-4.

ObjectiveTo report the sublingual microcirculation observed using Sidestream Dark Field imaging in two children with dengue shock.MethodTwo children, aged 9 and 10 years, were admitted to the pediatric intensive care unit with dengue shock and multiple organ dysfunction. Sublingual microcirculation was assessed in each patient on the first and second days of shock and was assessed a final time when the patients were no longer in shock (on the day prior to extubation) using Sidestream Dark Field technology. The De Backer score and microvascular flow index were used for the analyses.ResultsBoth patients had reduced perfused small vessel density in the first two days and showed predominantly intermittent or no microcirculation flow, as demonstrated by a low microvascular flow index. The blood flow in the large vessels was not affected. Prior to the extubation, the microvascular flow index had increased, although the perfused small vessel density remained diminished, suggesting persistent endothelial dysfunction.ConclusionsSevere microcirculation changes may be involved in the pathophysiological mechanisms that lead to the final stages of dengue shock, which is frequently irreversible and associated with high mortality rates. Microcirculatory monitoring may help elucidate the physiopathology of dengue shock and prove useful as a prognostic tool or therapeutic target.

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