• Critical care clinics · Jan 2006

    Review

    Glucose metabolism and insulin therapy.

    • Lies Langouche and Greet Van den Berghe.
    • Department of Intensive Care Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
    • Crit Care Clin. 2006 Jan 1;22(1):119-29, vii.

    AbstractHyperglycemia is a common feature of the critically ill patient and has been associated with increased mortality. Maintaining normoglycemia with insulin therapy improves survival and reduces morbidity in surgical ICU patients, as shown by a large randomized controlled study. Prevention of glucose toxicity by strict glycemic control but also other metabolic and non-metabolic effects of insulin contribute to these clinical benefits.

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