• R G Mitchell, U M Guly, T H Rainer, and C E Robertson.
• Department of Accident and Emergency Medicine and Surgery, The Royal Infirmary of Edinburgh, UK.
• Resuscitation. 2000 Jan 1;43(2):95-100.

ObjectiveTo examine the impact of administration of cardioactive drugs on the outcome from out of hospital cardiac arrest.DesignLongitudinal observational cohort study with historical controls before and after the introduction of drug use in cardiac arrest by paramedics.SubjectsAdult patients who had sustained an out of hospital cardiac arrest of cardiac aetiology and were treated by paramedics.SettingEdinburgh, Scotland.Outcome MeasuresReturn of spontaneous circulation, admission to and discharge from hospital.ResultsThere was no significant difference in the demographics between Period 1 (prior to drug administration) and Period 2 (after). There was no difference in outcome between Period 1 and Period 2 for all three parameters, return of spontaneous output 30.1 versus 35%, admission to hospital 18.9 versus 24.5% and discharge 5.8 versus 6.5%. If the presenting rhythm of VF/pulseless VT alone was considered survival to hospital discharge was 12.1% in Period 1 and 10.3% in Period 2.ConclusionThe addition of cardioactive drug administration to the treatment of out of hospital cardiac arrest does not improve survival.

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