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- Sarah K Kaufman and Marc I Diamond.
- Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA.
- Neurotherapeutics. 2013 Jul 1;10(3):371-82.
AbstractMany neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.
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