• Kanchana Rangarajan, Arulselvi Subramanian, Jatin S Gandhi, Namit Saraf, Vijay Sharma, and Kamran Farooque.
• Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
• J Emerg Trauma Shock. 2010 Jan 1;3(1):4-8.

BackgroundHead injury, severe acidosis, hypothermia, massive transfusion and hypoxia often complicate traumatic coagulopathy. First line investigations such as prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen level, platelet count and D-dimer levels help in the initial assessment of coagulopathy in a trauma victim.AimTo study the coagulation profile in patients of orthopedic trauma.Settings And DesignProspective study.Patients And MethodsPatients with head injury, severe acidosis, massive transfusion and severe hypoxia were excluded from the study. Coagulation parameters were evaluated at three intervals, at the time of admission, intra operatively and in the postoperative period.Statistical AnalysisChi-square test was used for analysis of categorical variables. For comparison between groups, two- way ANOVA was used.Results And ConclusionsOf the 48 patients studied, 38 (80%) had normal DIC scores upon admission and only 10 (20%) had mild DIC scores at the time of admission. The median Injury Severity Score was 34 and they did not correlate with DIC scores. Fibrinogen levels alone were significantly different, increased progressively (mean pre op, intra op and post op levels 518 +/- 31,582 +/- 35 and 643 +/- 27 respectively; P

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