• Donald E Fry.
• Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. dfry@consultmpa.com
• Am. J. Surg. 2011 Aug 1;202(2):225-32.

BackgroundColon preparation for elective colon resection to reduce surgical site infection (SSI) remains controversial.MethodsA review of the published literature was undertaken to define evidence-based practices for colon preparation for elective colon resection.ResultsSeventy years of surgical literature has documented that mechanical bowel preparation alone does not reduce SSI. A body of clinical trials has documented the benefits of oral antibiotic bowel preparation compared with a placebo in the reduction of SSI. Clinical trials show the addition of the oral antibiotic bowel preparation to appropriate systemic preoperative preventive antibiotics provide the lowest rates of SSI.ConclusionsMechanical bowel preparation alone does not reduce rates of SSI, but oral antibiotic preparation and systemic preoperative antibiotics are superior when compared with systemic antibiotics alone. Additional clinical trials are necessary to define the best combined overall mechanical and oral antibiotic regimen for elective colon surgery.Copyright © 2011 Elsevier Inc. All rights reserved.

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