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Cerebrovascular diseases · Jan 2006
New modalities and aspects of antiplatelet therapy for stroke prevention.
- Shinichiro Uchiyama, Tomomi Nakamura, Masako Yamazaki, Yumi Kimura, and Makoto Iwata.
- Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. suchiyam@nij.twmu.ac.jp
- Cerebrovasc. Dis. 2006 Jan 1;21 Suppl 1:7-16.
AbstractAntiplatelet therapy is indicated for secondary prevention of ischaemic stroke. The first-line antiplatelet agent is aspirin. The effect of aspirin is, however, very limited, and this limited effect of aspirin is argued with termed 'aspirin resistance'. Strategies against aspirin resistance may include alternative use of other antiplatelet agents, combination of aspirin with other antiplatelet agents and investigation into molecular targets to develop novel antiplatelet agents. Progress in antiplatelet therapy should be directed at further reducing the risk of ischaemic events including ischaemic stroke without increasing the risk of haemorrhagic events including haemorrhagic stroke.Copyright (c) 2006 S. Karger AG, Basel.
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