• Iowa Orthop J · Jan 2012

    Assessment of Mastergraft(®) strip with bone marrow aspirate as a graft extender in a rabbit posterolateral fusion model.

    • Joseph D Smucker, Emily B Petersen, James V Nepola, and Douglas C Fredericks.
    • The University of Iowa Department of Orthopaedics and Rehabilitation, Iowa City, Iowa 52242, USA.
    • Iowa Orthop J. 2012 Jan 1;32:61-8.

    Study Design/SettingRandomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes.ObjectiveThe Purpose of this study is to determine the performance characteristics of Mastergraft(®) Strip with bone marrow aspirate (BMA) as a bone graft extender in a rabbit posterolateral spine fusion model.Summary Of Background DataThe rabbit posterolateral fusion model is an established environment for testing of fusion concepts. It offers the opportunity to obtain radiographic, histological, and biomechanical data on novel fusion materials.MethodsThirty six rabbits were entered into the study with 34 used for analysis. Bilateral posterolateral lumbar intertransverse fusions were performed at L5-L6. the lateral two thirds of the transverse processes were decorticated and covered with graft material: autograft only (2.5 - 3.0 cc/side), 75% Mastergraft(®) Strip + 5.0 cc BMA / 25% autograft (3.0 cc total per side), or 50% Mastergraft(®) Strip + 5.0cc BMA and 50% autograft (3.0 cc total per side). Animals were humanely euthanized at 8 weeks post surgery.ResultsThe autograft group had a 60% radiographic fusion rate (6/10) and a manual palpation fusion rate of 50% (5/10). the 50% Mastergraft(®) Strip group had a 75% radiographic and manual palpation fusion rate (9/12). the 75% Mastergraft(®) Strip group demonstrated a 58% (7/12) radiographic and manual palpation fusion rate. Histologically, no adverse inflammatory reactions of significant size were present. The two Mastergraft(®) Strip groups demonstrated a tendency towards more bone development across the fusion bed.ConclusionsIn this commonly used rabbit posterolateral fusion model, Mastergraft(®) Strip with BMA in an autograft extender mode produces biomechanical and radiographic results similar to autograft fusion alone.

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