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Comparative Study
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
- Mathias Karlsson, James R Tooley, Saulius Satas, Catherine E Hobbs, Ela Chakkarapani, Janet Stone, Helen Porter, and Marianne Thoresen.
- Clinical Science at South Bristol (Child Health), University of Bristol, Bristol, BS2 8EG, United Kingdom.
- Pediatr. Res. 2008 Jul 1;64(1):74-8.
AbstractThe neuroprotective efficacy of hypothermia (HT) after hypoxia-ischemia (HI) falls dramatically the longer the delay in initiating HT. Knowledge is scarce regarding protective or adverse effects of HT in organs beyond the brain. In addition, the relative effectiveness of selective head cooling (SHC) and whole body cooling (WBC) has not been studied. We aimed to examine whether 24 h HT, initiated 3 h after global HI is brain- and/or organ-protective using pathology, neurology, and biochemical markers. Fifty,
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