• Ann. N. Y. Acad. Sci. · Feb 2007

    Quantitative EEG and electromagnetic brain imaging in aging and in the evolution of dementia.

    • Leslie S Prichep.
    • Brain Research Laboratories, Department of Psychiatry, New York University School of Medicine, New York 10016, USA. leslie.prichep@med.nyu.edu
    • Ann. N. Y. Acad. Sci. 2007 Feb 1;1097:156-67.

    AbstractElectroencephalographic (EEG) changes with normal aging have long been reported. Departures from age-expected changes have been observed in mild cognitive impairment and dementia, the magnitude of which correlates with the degree of cognitive impairment. Such abnormalities include increased delta and theta activity, decreased mean frequency, and changes in coherence. Similar findings have been reported using magnetoencephalography (MEG) at rest and during performance of mental tasks. Electrophysiological features have also been shown to be predictive of future decline in mild cognitive impairment (MCI) and Alzheimer's disease (AD). We have recently reported results from initial quantitative electroencephalography (QEEG) evaluations of normal elderly subjects (with only subjective reports of memory loss), predicting future cognitive decline or conversion to dementia, with high prediction accuracy (approximately 95%). In this report, source localization algorithms were used to identify the mathematically most probable underlying generators of abnormal features of the scalp-recorded EEG from these patients with differential outcomes. Using this QEEG method, abnormalities in brain regions identified in studies of AD using MEG, MRI, and positron emission tomography (PET) imaging were found in the premorbid recordings of those subjects who go on to decline or convert to dementia.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.