• Agents Actions Suppl. · Jan 1993

    Review

    Substance P and inflammatory pain: potential of substance P antagonists as analgesics.

    • J L Henry.
    • Department of Physiology, McGill University, Montreal, Quebec, Canada.
    • Agents Actions Suppl. 1993 Jan 1;41:75-87.

    AbstractSubstance P has been implicated in peripheral inflammatory responses and recent evidence from animal models indicates that substance P (NK-1 receptor) antagonists are effective in blocking peripheral inflammatory responses as well as nociception (pain) associated with inflammation. Evidence implicating substance P in nociception is reviewed in this survey, along with evidence on the effects of NK-1 receptor antagonists and with some comments on the usefulness of such antagonists as analgesics.

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