• Anesthesia and analgesia · Dec 2011

    Review Case Reports

    Apparent dexmedetomidine-induced polyuric syndrome in an achondroplastic patient undergoing posterior spinal fusion.

    • Allison Greening, Letha Mathews, and James Blair.
    • Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232-7237, USA. allison.greening@gmail.com
    • Anesth. Analg.. 2011 Dec 1;113(6):1381-3.

    AbstractA 40-year-old achondroplastic patient underwent posterior spinal fusion under general endotracheal anesthesia. Anesthesia was maintained with isoflurane, and sufentanil, dexmedetomidine, and lidocaine infusions. Urine output increased from 150 mL/hr to 950 mL/hr the fourth hour. An increasing serum sodium, low urine-specific gravity, and increased serum osmolarity occurred simultaneously with the polyuria. Within 2 hours of discontinuing the dexmedetomidine infusion urine output greatly decreased. Within 24 hours all signs of the polyuric syndrome resolved spontaneously. Alpha(2) agonists block arginine-vasopressin release and action; however, a polyuric syndrome has not been reported in the human literature.

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