• To Isesele, Fe Amadasun, and Np Edomwonyi.
• J West Afr Coll Surg. 2012 Oct 1;2(4):51-67.

BackgroundSuxamethonium is a depolarising muscle relaxant that provides rapid, excellent intubating condition and ease of intubation. Its adverse effects has led to the search for comparable alternatives. Propofol alone provides fair intubating conditions and ease of tracheal intubation. Addition of intravenous lidocaine to propofol has been reported to enhance intubating conditions.AimThe study compared the intubating conditions and ease of tracheal intubation following intravenous administration of propofol and suxamethonium (PS) with propofol and lidocaine (PL).Setting Of The StudyThe study was carried out in the department of Anaesthesia of the University of Benin Teaching Hospital, Benin City, Edo state, Nigeria.Design Of The StudyThis is a prospective randomized double-blinded controlled study. Ethical approval was obtained from the University of Benin Ethics and Research committee.Materials And MethodsEighty-eight eligible patients, aged 18-45 years, were prospectively randomized to 2 groups, PS and PL. Group PS received 2mg/kg propofol and 1.5mg/kg suxamethonium. Group PL had 2mg/kg propofol and 1.5mg/kg intravenous lidocaine. Intubating condition was determined, using a scale of 0 - 6 derived from jaw relaxation, ease of intubation and reflex response to intubation. Intubating condition was scored as good = 5-6, moderate = 3-4 and poor = 0-2.ResultsThe propofol-suxamethonium (PS) group had 100% good intubating condition and successful intubation. The propofol-lidocaine (PL) group had 59.1% moderate and 11.3% poor intubating conditions, with 70.5% successful and 29.5% failed intubation rates respectively.ConclusionLaryngoscopy and endotracheal intubation are possible with appropriate doses of propofol and lidocaine, without the use of suxamethonium.

5 keywords...

hide…