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- M D Hill, T Lye, H Moss, P A Barber, A M Demchuk, N J Newcommon, T L Green, C Kenney, A Cole-Haskayne, and A M Buchan.
- Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada. michael.hill@calgaryhealthregion.ca
- Neurology. 2003 May 13;60(9):1525-7.
AbstractOne hundred seventy-six consecutive patients treated with IV tissue plasminogen activator (tPA) for acute ischemic stroke were examined prospectively, and orolingual angioedema was found in nine (5.1%; 95% CI 2.3 to 9.5). The reaction was typically mild, transient, and contralateral to the ischemic hemisphere. Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0).
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