• Anesthesia and analgesia · Jan 2010

    The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1.

    • Michael Bernateck, Matthias Karst, Klaus F Gratz, Geerd J Meyer, Michael J Fischer, Wolfram H Knapp, Wolfgang Koppert, and Thomas Brunkhorst.
    • Department of Anesthesiology, Pain Clinic, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany. bernateck.michael@mh-hannover.de
    • Anesth. Analg. 2010 Jan 1;110(1):211-5.

    AbstractTumor necrosis factor (TNF)-alpha has been identified as a pathogenic factor in many immunologically based diseases and complex regional pain syndrome (CRPS). In this case series, we used radiolabeled technetium anti-TNF-alpha antibody to scintigraphically image TNF-alpha in 3 patients with type 1 CRPS. The results show that TNF-alpha was localized only in affected hands of patients with early-stage CRPS. No uptake was seen in clinically unaffected hands and late-stage CRPS. Our findings support the growing evidence for neuroimmune disturbance in patients with CRPS and may have important further implications for specific anticytokine treatment in patients with CRPS.

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