• Peng Shao, Da-Jun Qu, Rui-Ying Song, Ming-Lu Chen, and Li-Hua Wang.
• Department of Rehabilitation Medicine, Yantaishan Hospital Yantai 264000, China.
• Int J Clin Exp Med. 2015 Jan 1;8(3):3429-37.

ObjectiveThe present study aims to evaluate the relation between PON1 L55M polymorphism and ischemic stroke by a meta-analysis method.MethodsEnglish and Chinese databases were retrieved to find qualified studies; a random or fixed effects model was used to merge the odds ratio (OR); Q test was used to assess the heterogeneity among studies, and Egger's test and funnel plot were used for the assessment of publication bias.Results14 studies were included in the meta-analysis; in total populations, there was no association between PON1 gene L55M polymorphism and ischemic stroke in additive, dominant, and recessive model, respectively. Furthermore, we did not found associations between L55M and ischemic stroke in Asian or Caucasian population.ConclusionAvailable evidences suggested that L55M polymorphism had no effect on the risk of ischemic stroke. However, this conclusion needs further validation by larger sample and well-designed studies.

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