• Blood purification · Jan 2014

    Effects of the volume of processed plasma on the outcome, arterial pressure and blood procalcitonin levels in patients with severe sepsis and septic shock treated with coupled plasma filtration and adsorption.

    • Giorgio Berlot, Antoinette Agbedjro, Ariella Tomasini, Francesco Bianco, Ugo Gerini, Marino Viviani, and Fabiola Giudici.
    • Department of Anaesthesia and Intensive Care Medicine, University of Trieste, Trieste, Italy.
    • Blood Purif. 2014 Jan 1;37(2):146-51.

    AimsTo understand how coupled plasma filtration and adsorption (CPFA) could influence the time course of the advanced stages of sepsis, mean arterial pressure (MAP) and norepinephrine dosage.MethodsPatients with severe sepsis and septic shock with ≥2 organ failures not responding to volume resuscitation and vasopressor infusion were treated with CPFA within 8 h of admission to the intensive care unit.ResultsThirty-nine patients were treated (median age: 63 years, median SAPS II score: 45) and 28 survived advanced sepsis. In the latter, the median MAP increased and the norepinephrine dosage decreased significantly after CPFA, whereas in the nonsurvivors these values did not change significantly. The volume of treated plasma was significantly higher in survivors than nonsurvivors.ConclusionThese results suggest a possible existence of a dose-response effect for CPFA. Future studies are therefore recommended to evaluate the efficacy of this treatment and to determine its best timing and intensity.

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