• J Orofac Pain · Jan 2006

    Randomized Controlled Trial

    Effects of local serotonin administration on pain and microcirculation in the human masseter muscle.

    • Malin Ernberg, Britt Hedenberg-Magnusson, Hiroshi Kurita, and Sigvard Kopp.
    • Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden. malin.ernberg@ki.se
    • J Orofac Pain. 2006 Jan 1;20(3):241-8.

    AimsTo investigate whether exogenously administered 5-hydroxytryptamine (5-HT) at high or low concentration influences pain and microcirculation in the human masseter muscle.MethodsIn 12 healthy female subjects, 5-HT in 2 concentrations (0.1 micromol/L and 1,000 micromol/L) and isotonic saline were injected into the masseter muscles in a randomized and balanced double-blind manner. The pain intensity after injections was recorded with Borg's rating scale, and intramuscular blood flow was monitored continuously during the experiment with a laser-Doppler technique. Nonparametric statistics were used for analyses.ResultsAdministration of 5-HT at 1,000 micromol/L induced significantly more pain than saline (Wilcoxon: P < .05), while there was no difference between 5-HT at 0.1 micromol/L and saline. The blood flow did not change significantly after injection of 5-HT at either concentration compared to saline. However, changes in pain intensity and blood flow were positively correlated after injection of 5-HT at 1,000 micromol/L (Spearman: P < .05).ConclusionIntramuscular administration of 5-HT at 1,000 micromol/L into the human masseter muscle induced pain, but 5-HT did not have any effect on local blood flow at either concentration.

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