• Michael F Shriver, Daniel J Lewis, Varun R Kshettry, Benjamin P Rosenbaum, Edward C Benzel, and Thomas E Mroz.
• Case Western Reserve University School of Medicine, 2109 Adelbert Rd, Cleveland, OH 44106, USA. Electronic address: mfs82@case.edu.
• Spine J. 2015 Sep 1;15(9):2016-27.

Background ContextAnterior cervical discectomy and fusion (ACDF) is a commonly performed procedure for patients presenting with cervical radiculopathy, myelopathy, or deformity. A systematic literature review and meta-analysis of pseudoarthrosis rates associated with ACDF with plate fixation have not been previously performed.PurposeThe purpose of this study was to identify all prospective studies reporting pseudoarthrosis rates for ACDF with plate fixation.Study Design/SettingThis study is based on a systematic review and meta-analysis.Patient SampleStudies reporting pseudoarthrosis rates in patients who received one-, two-, or three-level ACDF surgeries were included.Outcome MeasuresOutcomes of interest included reported pseudoarthrosis events after ACDF with plate fixation.MethodsWe conducted a MEDLINE, SCOPUS, Web of Science, and EMBASE search for studies reporting complications for ACDF with plate fixation. We recorded pseudoarthrosis events from all included studies. A meta-analysis was performed to calculate effect summary mean values, 95% confidence intervals (CIs), Q statistics, and I(2) values. Forest plots were constructed for each analysis group.ResultsOf the 7,130 retrieved articles, 17 met the inclusion criteria. The overall pseudoarthrosis rate was 2.6% (95% CI: 1.3-3.9). Use of autograft fusion (0.9%, 95% CI: -0.4 to 2.1) resulted in a reduced pseudoarthrosis rate compared with allograft fusion procedures (4.8%, 95% CI: 1.7-7.9). Studies were separated based on the length of follow-up: 12 to 24 and greater than 24 months. These groups reported rates of 3.1% (95% CI: 1.2-5.0) and 2.3% (95% CI: 0.1-4.4), respectively. Studies performing single-level ACDF yielded a rate of 3.7% (95% CI: 1.6-5.7). Additionally, there was a large difference in the rate of pseudoarthrosis in randomized controlled trials (4.8%, 95% CI: 2.6-7.0) versus prospective cohort studies (0.2%, 95% CI: -0.1 to 0.5), indicating that the extent of follow-up criteria affects the rate of pseudoarthrosis.ConclusionsThis review represents a comprehensive estimation of the actual incidence of pseudoarthrosis across a heterogeneous group of surgeons, patients, and ACDF techniques. The definition of pseudoarthrosis varied significantly within the literature. To ensure its diagnosis and prevent sequelae, standardized criteria need to be established. This investigation sets the framework for surgeons to understand the impact of surgical techniques on the rate of pseudoarthrosis.Copyright © 2015 Elsevier Inc. All rights reserved.

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