• S. Afr. Med. J. · Mar 1975

    Defibrination in obstetrics. Modern concepts.

    • G J Kleiner and W M Greston.
    • S. Afr. Med. J. 1975 Mar 19;49(12):446-52.

    AbstractCoagulation profiles of serum fibrinogen, factors V and VIII and haemoglobin in normal pregnancies during labour, delivery and the early puerperium are presented. These factors were also studied in patients with abruptio placentae, in intra-uterine death, and in patients whose pregnancies were terminated with intra-amniotic saline and prostaglandin F2alpha. An assessment of fibrinolytic activity in these patients was made using qualitative (euglobulin lysis time) and quantitative (FR-antigen) tests. The coagulation findings presented form a basis for the rational management of defibrination in obstetrics.

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