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Neuroscience letters · Oct 2010
CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain.
- Norikazu Kiguchi, Yuka Kobayashi, Takehiko Maeda, Fumihiro Saika, and Shiroh Kishioka.
- Department of Pharmacology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.
- Neurosci. Lett. 2010 Oct 22;484(1):17-21.
AbstractWe investigated the involvement of spinal macrophage inflammatory protein-1α (MIP-1α), an inflammatory chemokine, in partial sciatic nerve ligation (PSL)-induced neuropathic pain in mice. PSL increased MIP-1α mRNA levels as well as levels of the MIP-1α receptor, CCR1, but not CCR5 in the spinal dorsal horn. PSL-induced tactile allodynia and thermal hyperalgesia were prevented by intrathecal (i.t.) injection of a neutralizing antibody of MIP-1α (2ng). Recombinant MIP-1α (10pmol, i.t.) elicited long-lasting tactile allodynia and thermal hyperalgesia in naïve mice. These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1α and CCR1 to participate in neuropathic pain.Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
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