• Psycho-oncology · Dec 2009

    Randomized Controlled Trial

    Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer.

    • Cecile A Lengacher, Versie Johnson-Mallard, Janice Post-White, Manolete S Moscoso, Paul B Jacobsen, Thomas W Klein, Raymond H Widen, Shirley G Fitzgerald, Melissa M Shelton, Michelle Barta, Matthew Goodman, Charles E Cox, and Kevin E Kip.
    • University of South Florida College of Nursing, Tampa, FL 33612-447, USA.
    • Psychooncology. 2009 Dec 1;18(12):1261-72.

    ObjectivesConsiderable morbidity persists among survivors of breast cancer (BC) including high levels of psychological stress, anxiety, depression, fear of recurrence, and physical symptoms including pain, fatigue, and sleep disturbances, and impaired quality of life. Effective interventions are needed during this difficult transitional period.MethodsWe conducted a randomized controlled trial of 84 female BC survivors (Stages 0-III) recruited from the H. Lee Moffitt Cancer and Research Institute. All subjects were within 18 months of treatment completion with surgery and adjuvant radiation and/or chemotherapy. Subjects were randomly assigned to a 6-week Mindfulness-Based Stress Reduction (MBSR) program designed to self-regulate arousal to stressful circumstances or symptoms (n=41) or to usual care (n=43). Outcome measures compared at 6 weeks by random assignment included validated measures of psychological status (depression, anxiety, perceived stress, fear of recurrence, optimism, social support) and psychological and physical subscales of quality of life (SF-36).ResultsCompared with usual care, subjects assigned to MBSR(BC) had significantly lower (two-sided p<0.05) adjusted mean levels of depression (6.3 vs 9.6), anxiety (28.3 vs 33.0), and fear of recurrence (9.3 vs 11.6) at 6 weeks, along with higher energy (53.5 vs 49.2), physical functioning (50.1 vs 47.0), and physical role functioning (49.1 vs 42.8). In stratified analyses, subjects more compliant with MBSR tended to experience greater improvements in measures of energy and physical functioning.ConclusionsAmong BC survivors within 18 months of treatment completion, a 6-week MBSR(BC) program resulted in significant improvements in psychological status and quality of life compared with usual care.

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