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Case Reports
[The serotonin syndrome. Fatal course of intoxication with citalopram and moclobemide].
- S Cassens, E A Nickel, M Quintel, and P Neumann.
- Zentrum Anästhesie, Rettungs- und Intensivmedizin, Universitätsklinikum, Robert-Koch-Strasse 40, 37075 Göttingen. scassens@zari.de
- Anaesthesist. 2006 Nov 1; 55 (11): 118911961189-96.
AbstractThe serotonin syndrome is caused by a drug-induced increase of the intrasynaptic serotonin concentration. Milder forms of the syndrome may be difficult to diagnose because of the variability of symptoms. Severe forms often rapidly turn into a life-threatening situation, therefore the serotonin syndrome may be a challenge for physicians. We describe the pathophysiology and therapeutic options of the serotonin syndrome and report about a 42-year-old female patient who ingested large amounts of moclobemide, a monoamine oxidase inhibitor, and citalopram, a selective serotonin reuptake inhibitor, for attempted suicide. Within a few hours the patient developed a lethal serotonin syndrome although ICU therapy was initiated immediately.
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