• J Pain Palliat Care Pharmacother · Jan 2004

    Review

    Opioid insights:opioid-induced hyperalgesia and opioid rotation.

    • Perry G Fine.
    • School of Medicine, Pain Management Center, University of Utah Health Sciences Center, Salt Lake City, UT, USA. fine@aros.net
    • J Pain Palliat Care Pharmacother. 2004 Jan 1;18(3):75-9.

    AbstractOpioid analgesics are an irreplaceable component of pharmacotherapy of numerous pain-producing conditions. Clinicians and patients must contend with the imperfect nature of this class of drugs, trying to balance benefits and burdens on a continual basis. New literature related to evidence-based selection of opioids and the neurobiological phenomenon of opioid induced hyperalgesia are reviewed. A matrix describing critical elements in the selection of opioid analgesics, both for initial therapy and for opioid rotation, is presented.

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