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Multicenter Study
Implications of adopting the Global Lungs Initiative 2012 all-age reference equations for spirometry.
- Philip H Quanjer, Danny J Brazzale, Piotr W Boros, and Jeffrey J Pretto.
- Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands.
- Eur. Respir. J. 2013 Oct 1;42(4):1046-54.
AbstractThe aim of this study was to determine the diagnostic and interpretative consequences of adopting the Global Lungs Initiative (GLI) 2012 spirometric prediction equations. We assessed spirometric records from 17 572 subjects (49.5% females), aged 18-85 years, from hospitals in Australia and Poland. We calculated predicted forced expiratory volume in 1 s (FEV1), forced expiratory volume (FVC), FEV1/FVC and lower limits of normal (LLN) using European Community for Steel and Coal (ECSC), National Health and Nutrition Examination Survey (NHANES) III and GLI 2012 equations. Obstruction was defined as FEV1/FVC
LLN and FVC 20% underdiagnosis of airway obstruction up to the age of 55 years and to 16-23% overdiagnosis in older subjects. GLI 2012 equations increase the prevalence of a "restrictive spirometric pattern" compared to ECSC but decrease it compared to NHANES. Notes
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