• Philippe Mathurin, Antoine Hollebecque, Laurent Arnalsteen, David Buob, Emmanuelle Leteurtre, Robert Caiazzo, Marie Pigeyre, Hélène Verkindt, Sébastien Dharancy, Alexandre Louvet, Monique Romon, and François Pattou.
• Service d'Hépato-Gastroentérologie, CHRU de Lille, Université Lille 2, France. p-mathurin@chru-lille.fr
• Gastroenterology. 2009 Aug 1;137(2):532-40.

Background & AimsSevere obesity is implicated in development of nonalcoholic fatty liver disease (NAFLD). Bariatric surgery induces weight loss and increases survival time of obese patients, but little is known about its effects on liver damage. We performed a 5-year prospective study to evaluate fibrosis and nonalcoholic steatosis (NASH) in severely obese patients after bariatric surgery.MethodsBariatric surgery was performed on 381 patients. Clinical and biological data, along with liver biopsies, were collected before and at 1 and 5 years after surgery.ResultsFive years after surgery, levels of fibrosis increased significantly, but 95.7% of patients maintained a fibrosis score ConclusionsFive years after bariatric surgery for severe obesity, almost all patients had low levels of NAFLD, whereas fibrosis slightly increased. Steatosis and ballooning were closely linked to IR; long-term effects could be predicted by early improvement in IR.

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