• J Richardson and K Bresland.
• Department of Anaesthetics, Bradford Royal Infirmary, England.
• Drug Aging. 1998 Jul 1;13(1):17-31.

AbstractIt is likely that the trend towards ever more aggressive surgery in elderly and possibly frail patients will continue, with the lifting of traditional age limits. Recent evidence has show that surgical trauma induces processes of nervous system sensitisation that contributes to and enhances postoperative pain and leads to chronic pain. This knowledge provides a rational basis for pro-active, pre-operative and post-operative analgesic strategies which can reduce the neuronal barrage associated with tissue damage. As well as a reduction or elimination of post-operative pain, an improvement in physiological variables, such as neuroendocrine stress responses and post-operative pulmonary function can be expected. Complete pain control cannot be achieved with a single agent or technique without significant serious adverse effects, a problem which is compounded in the elderly patient due to a combination of slower drug metabolism, decreased organ function and physiological changes in cardiovascular and respiratory reserves. A balanced analgesic regimen that includes an effective afferent block (regional analgesia) is more appropriate. By preventing postoperative pain and its associated neuroendocrine sequelae, major surgical procedures in traditionally unsuitable patients can be seriously considered.

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