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- M A Giamberardino, G Affaitati, R Valente, S Iezzi, and L Vecchiet.
- Pathophysiology of Pain Laboratory, Institute of Medical Pathophysiology G. D'Annunzio University of Chieti, Italy. mag@unich.it
- Brain Res. 1997 Nov 7;774(1-2):234-8.
AbstractThis study examined estrous differences in the characteristics of behavioral crises of visceral pain in female rats video-taped throughout a 4-day period after implantation of an artificial stone in one ureter. All animals continued to have a regular cycle after ureteral surgery. In the recording period, the percentage of time spent in crises was significantly higher during metestrus/diestrus (M/D) than during proestrus/estrus (P/E) (P < 0.001, chi2-test). Mean duration and complexity of crises were slightly higher in M/D than in P/E, but the difference was not significant. The results in this animal model show an enhancement of ureteral pain sensitivity in M/D, a finding in line with the clinical observation, in fertile women with urinary calculosis, of a greater incidence of colics in the perimenstrual period (equivalent to M/D in rats).
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