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Anesthesia and analgesia · Dec 2011
Comparative StudyIsoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion.
- Eric Noll, Olivier Collange, Anne-Laure Charles, Jamal Bouitbir, Joffrey Zoll, François Piquard, and Bernard Geny.
- Pôle Anesthésie Réanimation Chirurgicale, SAMU, Hôpitaux Universitaires de Strasbourg, Avenue Molière, 67098 Strasbourg, France. olivier.collange@chru-strasbourg.fr
- Anesth. Analg.. 2011 Dec 1;113(6):1438-41.
BackgroundLung and liver dysfunction is involved in gut ischemia-reperfusion (IR)-induced multiple organ failure. We compared the effects of ketamine and isoflurane on liver and lung mitochondrial oxidative capacity after gut IR.MethodsAdult male Wistar rats were randomized into 4 groups (controls and gut IR receiving either intraperitoneal ketamine or inhaled isoflurane). Maximal oxygen consumption and the activity of respiratory chain complexes were measured on isolated liver and lung mitochondria.ResultsGut IR significantly impaired liver and lung mitochondrial oxidative capacity when using ketamine but not isoflurane.ConclusionsIsoflurane preserved liver and lung mitochondrial oxidative capacity after gut IR.
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