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Biological psychology · Feb 2008
Randomized Controlled Trial Comparative StudyEffects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals.
- Christopher Ring, Christopher R France, Mustafa al'Absi, Louisa Edwards, David McIntyre, Douglas Carroll, and Una Martin.
- International Centre for Health and Exercise Research, University of Birmingham, Birmingham B15 2TT, UK. c.m.ring@bham.ac.uk
- Biol Psychol. 2008 Feb 1;77(2):191-6.
AbstractAn opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.
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