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Curr. Opin. Pediatr. · Apr 2012
ReviewClinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents in children.
- Cyril Sahyoun and Baruch Krauss.
- Division of Emergency Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. cyril.sahyoun@childrens.harvard.edu
- Curr. Opin. Pediatr. 2012 Apr 1;24(2):225-32.
Purpose Of ReviewProcedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department.Recent FindingsNumerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized.SummaryWe review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.
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