• A Tenling, P O Joachimsson, H Tydén, G Wegenius, and G Hedenstierna.
• Department of Cardiothoracic Anesthesiology, University Hospital, Uppsala, Sweden.
• J. Cardiothorac. Vasc. Anesth. 1999 Jun 1;13(3):258-64.

ObjectiveTo determine the effects of thoracic epidural anesthesia (TEA) on ventilation-perfusion (VA/Q) relationships, atelectasis, and oxygenation before and after coronary artery bypass graft surgery (CABG).DesignProspective, controlled, unblinded, randomized trial.SettingCardiothoracic clinic at a major university referral center.ParticipantsTwenty-eight patients undergoing elective CABG.InterventionsPerioperative and postoperative TEA was added to general anesthesia (GA) in 14 patients, and 14 patients receiving GA alone served as controls.Measurements And Main ResultsVA/Q relationships were measured by the multiple inert gas elimination technique, and, 20 hours postoperatively, atelectasis was assessed by computerized tomographic scans. Arterial and mixed venous blood gases and hemodynamic variables were measured by standard techniques. TEA per se caused no change in shunt, VA/Q matching, or oxygenation. Induction of GA in the control group and induction of TEA caused similar reductions in mean arterial pressure. The TEA patients needed less morphine analgesia postoperatively and were extubated earlier. Extubation caused significant improvement in VA/Q matching. On the first postoperative day, a slight reduction in PaCO2 was seen in the TEA group, but no differences in shunt, VA/Q matching, or oxygenation compared with the GA group. Both groups showed extensive bilateral atelectasis.ConclusionTEA can reduce respirator time and the need for morphine analgesics after CABG without negative effects on VA/Q matching, oxygenation, or atelectasis formation.

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