• Juliane Prieto Peres Mercante, Marcio Antonini Bernik, Vera Zukerman-Guendler, Eliova Zukerman, Evelyn Kuczynski, and Mario Fernando Prieto Peres.
• Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Rua Maestro Cardim 887, 01323-001 São Paulo, SP, Brazil. julianeperes@terra.com.br
• Arq Neuropsiquiatr. 2007 Sep 1;65(3B):880-4.

IntroductionChronic migraine is a common, debilitating condition affecting quality of life and social functioning with significant impact. Migraine is highly comorbid with anxiety and mood disorders, but little is known about psychiatric comorbidities impact in the migraine patient quality of life.MethodFifty patients with chronic migraine diagnosed according to the International Headache Society (2004) were interviewed and met diagnostic criteria for mental disorders, according to the structured interview SCID-I/P and were evaluated by the SF-36 Health Survey questionnaire. Patients were divided in the following groups: chronic migraine with both mood and anxiety disorders, with only anxiety disorders, with generalized anxiety disorder, with only a mood disorder, and without psychopathology. The scores in the group without psychopathology were compared with the other groups. All eight domains of the SF-36 scale were compared in those groups.ResultsSignificantly lower (p<0.05) quality of life was found on all eight SF-36 domains for CM psychiatric comorbidity patients compared to no-co morbidity patients. On the SF-36 General Health domain alone, quality of life was not significantly lower for all four CM psychiatric comorbidity groups. On the SF-36 Physical Aspects domain alone, quality of life was not significantly lower only for the Anxiety Disorders group.ConclusionChronic migraine comorbidity with mental disorder is a significant factor affecting patients' quality of life.

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