• Neuroscience research · Jun 2015

    Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush.

    • Alessandro Gallo, Andrea Dimiziani, Jonathan Damblon, Benoît Michot, Anne Des Rieux, Marc De Kock, Emmanuel Hermans, and Ronald Deumens.
    • Institute of Neuroscience, Université catholique de Louvain, Avenue Hippocrate B1.54.10, 1200 Brussels, Belgium.
    • Neurosci. Res. 2015 Jun 1;95:78-82.

    AbstractSpinal glial reactivity has been strongly implicated in pain that follows peripheral nerve injury. Among the many therapeutic agents that have been tested for anti-allodynia through immune modulation is the atypical methylxanthine propentofylline. While propentofylline shows a potent anti-allodynia effect after nerve transection injury, we here demonstrate that, when propentofylline is used intrathecally at the effective immune-modulatory dose, allodynia after rat nerve crush injury is completely preserved. Microglial/macrophage Iba-1 and astrocytic GFAP expression, increased in the dorsal horn of nerve crushed animals, was, however, effectively attenuated by propentofylline. Effective modulation of spinal glial reactivity is, thus, no assurance for anti-allodynia.Copyright © 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

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