• S A Jenkins and C F Marshall.
• Department of Anaesthesia, Queen Elizabeth Hospital, Woodville, South Australia.
• Anaesth Intensive Care. 2000 Oct 1;28(5):556-61.

AbstractThis study examined the efficacy of a technique of administration of lignocaine 2% (with 1:200,000 adrenaline) to the nose, pharynx and larynx. A simple device constructed from a 22 gauge Optiva cannula attached to a medical oxygen supply via green "bubble" tubing and the barrel of a 3 ml syringe, similar to that described by Mackenzie, was used to administer aerosolized lignocaine initially via the nose and subsequently via a nasopharyngeal airway. Ten unsedated, unpremedicated volunteers were intubated. The mean time from the start of the administration of lignocaine to confirmation of placement of the endotracheal tube was 12 minutes (range 8 to 19 minutes). Intubating conditions were good and the procedure was well tolerated in all subjects. The mean dose of lignocaine was 4.8 mg.kg-1 (range 2.7 to 6.9 mg.kg-1) and plasma concentrations were well below toxic levels (highest concentration 3.12 mg.l-1). There was good haemodynamic stability and no episode of oxyhaemoglobin desaturation.

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