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Acta Neurochir. Suppl. · Jan 2003
Comparative StudyEffect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine.
- J W Chang, J S Yang, M F Jeon, B H Lee, and S S Chung.
- Department of Neurosurgery, Medical Research Center, Brain Korea 21 project for Medical Science & Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. jchang@yumc.yonsei.ac.kr
- Acta Neurochir. Suppl. 2003 Jan 1;87:163-8.
AbstractThe aim of the present study was to investigate the alteration of neuronal activities in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), after ipsilateral STN lesioning by kainic acid in the rat hemi-parkinsonian 6-hydroxydopamine (6-OHDA) model. In various rat Parkinson's disease (PD) models, an increase in the SNpr firing rate was observed, despite the occurrence of bursting patterns, and subthalamic lesion was found to reduce the mean firing rates and the percentage of bursting neurons in the SNpr. However, the relative proportion of bursting neurons, among all GP neurons, was slightly increased as a result of the subthalamic lesion. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism behind Parkinson's disease.
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