• Yakup UStün, Ozgür Erdogan, Emin Esen, and Ebru Deniz Karsli.
• Cukurova University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adana, Turkey. yustun@cu.edu.tr
• Oral Surg Oral Med O. 2003 Nov 1;96(5):535-9.

ObjectiveThe aim of this study was to compare the effects of intravenous administration of 1.5 mg/kg and 3 mg/kg of methylprednisolone sodium succinate (MP) on pain, swelling, and trismus after third molar surgery.Study DesignTwenty-six healthy patients with symmetrically impacted mandibular third molars were included in this double-blind, cross-over study. Either 1.5 mg/kg or 3 mg/kg of MP was administered by intravenous route one hour prior to the first operation. At the second operation the other dose was applied. Trismus was determined by measuring maximum interincisal opening and facial swelling was evaluated using a tape measuring method. Pain was determined using visual analogue scale and recording the number of pain pills taken.ResultsThere was no statistically significant difference in trismus, facial swelling, and pain between the two groups.ConclusionNo clinical benefit of the higher dose of MP was demonstrated.

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