• Amanda M Rosenblum, Lucy D Horvat, Laura A Siminoff, Versha Prakash, Janice Beitel, and Amit X Garg.
• Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Canada.
• Nephrol. Dial. Transplant. 2012 Jun 1;27(6):2533-46.

BackgroundThe degree of involvement by the next-of-kin in deceased organ procurement worldwide is unclear. We investigated the next-of-kin's authority in the procurement process in nations with either explicit or presumed consent.MethodsWe collected data from 54 nations, 25 with presumed consent and 29 with explicit consent. We characterized the authority of the next-of-kin in the decision to donate deceased organs. Specifically, we examined whether the next-of-kin's consent to procure organs was always required and whether the next-of-kin were able to veto procurement when the deceased had expressed a wish to donate.ResultsThe next-of-kin are involved in the organ procurement process in most nations regardless of the consent principle and whether the wishes of the deceased to be a donor were expressed or unknown. Nineteen of the 25 nations with presumed consent provide a method for individuals to express a wish to be a donor. However, health professionals in only four of these nations responded that they do not override a deceased's expressed wish because of a family's objection. Similarly, health professionals in only four of the 29 nations with explicit consent proceed with a deceased's pre-existing wish to be a donor and do not require next-of-kin's consent, but caveats still remain for when this is done.ConclusionsThe next-of-kin have a considerable influence on the organ procurement process in both presumed and explicit consent nations.

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