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Case Reports
[Should we care about pregabalin for elderly patients with a history of cardiac dysrhythmia?].
- M-A Laville, B de la Gastine, B Husson, R Le Boisselier, B Mosquet, and A Coquerel.
- Centre régional de pharmacovigilance de Basse-Normandie, CHRU Côte-de-Nacre, 14033 Caen cedex, France. lavillema@yahoo.fr <lavillema@yahoo.fr>
- Rev Med Interne. 2008 Feb 1;29(2):152-4.
AbstractPregabalin is similar in structure to gamma-aminobutyric acid. It is used for neuropathic pain, generalized anxiety disorders and as an adjunct therapy for partial seizures. Tachycardia is a rare side-effect. A 92-year-old patient with a history of paroxystic fibrillation was hospitalised for zoster. She developed a sinusal tachycardia followed by atrial fibrillation and congestive heart failure 15 h after a first dose of pregabalin. The imputation was considered as plausible. Even though the mechanism remains unclear, pregabalin might induce tachycardia in predisposed old patients.
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