• Clin J Pain · Oct 2014

    Multicenter Study Comparative Study Observational Study

    Effectiveness of Duloxetine Compared to Pregabalin and Gabapentin in Diabetic Peripheral Neuropathic Pain: Results From A German Observational Study.

    • Michael Happich, Edith Schneider, Frank G Boess, Stefan Wilhelm, Alexander Schacht, Frank Birklein, and Dan Ziegler.
    • *Medical Department, Health Technology Appraisal Group †Regional Medical Affairs ‡Global Statistical Sciences, Lilly Deutschland GmbH, Bad Homburg §Klinik und Poliklinik für Neurologie, Johannes Gutenberg Universität, Mainz ∥Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University ¶Department of Endocrinology and Diabetology, University Hospital, Düsseldorf, Germany.
    • Clin J Pain. 2014 Oct 1;30(10):875-85.

    ObjectivesThis study aimed to compare the effectiveness of duloxetine (DLX) and the anticonvulsants pregabalin (PGB) and gabapentin (GBP) for the treatment of diabetic peripheral neuropathic pain (DPNP) in routine clinical care.Materials And MethodsData from a 6-month, noninterventional study involving 2575 patients in whom treatment of DPNP was initiated with or changed to DLX, PGB, or GBP (n=1523) were analyzed post hoc; patients treated with other medications or combinations were excluded from this analysis. Propensity scoring was used to compare patient groups, assessing Brief Pain Inventory (BPI), Clinical and Patient Global Impression (CGI/PGI), the Hospital Anxiety and Depression Scale (HADS), the Sheehan Disability Scale (SDS), and the Short Form Health Survey (SF 12).ResultsMean median daily dosage over 6 months was 53.9 mg for DLX (N=931), 173.5 mg for PGB (N=248), and 727.8 mg for GBP (N=351). BPI average pain severity (last observation carried forward, mean [SD]) decreased by 2.3 [2.30] points for DLX patients, and by 1.9 [2.22] in PGB, and 1.1 [2.15] in GBP patients. This difference remained statistically significant (DLX vs. PGB: P=0.029; DLX vs. GBP: P<0.001) after adjustment by propensity scores. Similar findings were also seen for the BPI interference score, CGI and PGI, the HADS anxiety score, the HADS depression score.DiscussionWhen compared with DLX, the low doses of PGB and GBP used in this noninterventional study might have contributed to the lower effectiveness found for both anticonvulsants in the treatment of patients with DPNP.

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