• Christopher G Hughes, Nathan E Brummel, Eduard E Vasilevskis, Timothy D Girard, and Pratik P Pandharipande.
• Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA. christopher.hughes@vanderbilt.edu
• Best Pract Res Clin Anaesthesiol. 2012 Sep 1; 26 (3): 395-405.

AbstractDelirium is a prevalent organ dysfunction in critically ill patients associated with significant morbidity and mortality, requiring advancements in the clinical and research realms to improve patient outcomes. Increased clinical recognition and utilisation of delirium assessment tools, along with clarification of specific risk factors and presentations in varying patient populations, will be necessary in the future. To improve predictive models for outcomes, the continued development and implementation of delirium assessment tools and severity scoring systems will be required. The interplay between the pathophysiological pathways implicated in delirium and resulting clinical presentations and outcomes will need to guide the development of appropriate prevention and treatment protocols. Multicentre randomised controlled trials of interventional therapies will then need to be performed to test their ability to improve clinical outcomes. Physical and cognitive rehabilitation measures need to be further examined as additional means of improving outcomes from delirium in the hospital setting.Copyright © 2012 Elsevier Ltd. All rights reserved.

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