• Respiratory investigation · May 2014

    Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of small cell lung cancer.

    • Yasushi Murakami, Masahide Oki, Hideo Saka, Chiyoe Kitagawa, Yoshihito Kogure, Misaki Ryuge, Rie Tsuboi, Saori Oka, Masashi Nakahata, Yoriko Funahashi, Kazumi Hori, Yuko Ise, Shu Ichihara, and Suzuko Moritani.
    • Department of Respiratory Medicine, Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan. Electronic address: konyasu222@gmail.com.
    • Respir Investig. 2014 May 1;52(3):173-8.

    BackgroundMassive lymphadenopathy and direct mediastinal invasion are well-recognized phenomena in patients with small cell lung cancer (SCLC). The aim of this study was to assess the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of SCLC.MethodsWe retrospectively reviewed the records of 780 patients who underwent EBUS-TBNA at our institution from March 2004 to June 2012. Of these, 101 had a final diagnosis of SCLC. Excluding 3 patients with known SCLC who underwent EBUS-TBNA for staging purposes and including 2 patients who underwent EBUS-TBNA twice for the diagnosis of recurrence after achieving complete response by chemoradiation therapy during the study period, a total of 100 EBUS-TBNA procedures in 98 patients were analyzed.ResultsOther diagnostic tests prior to the initial EBUS-TBNA had failed to yield a diagnosis in 41 patients. The overall diagnostic yield of EBUS-TBNA for SCLC was 97% (97 of 100). Rapid on-site cytologic evaluation (ROSE) was performed at the operator's discretion in 77 procedures. ROSE did not have any impact on diagnostic yield (99% with ROSE vs. 90% without ROSE, p=0.1), but the use of ROSE was associated with fewer lesions (mean 1.1 with ROSE vs. 1.6 without ROSE, p<0.01) or aspirates (mean 2.3 with ROSE vs. 4.0 without ROSE, p<0.01).ConclusionsEBUS-TBNA provided a high diagnostic yield in SCLC with or without ROSE. EBUS-TBNA can be recommended for patients suspected to have SCLC, even if other diagnostic tests have failed.© 2013 Published by The Japanese Respiratory Society on behalf of The Japanese Respiratory Society.

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