-
Historical Article
Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA.
- Helen D Donoghue, Mark Spigelman, Charles L Greenblatt, Galit Lev-Maor, Gila Kahila Bar-Gal, Carney Matheson, Kim Vernon, Andreas G Nerlich, and Albert R Zink.
- Centre for Infectious Diseases and International Health, University College London, London, UK.
- Lancet Infect Dis. 2004 Sep 1;4(9):584-92.
AbstractDuring the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions and shown changes to pathogens over time. However, ancient DNA (aDNA) continues to be controversial and great care is needed to provide valid data. Here we review the most successful application of the technology, which is the study of tuberculosis. This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..