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- Alexandra Binnie, Jennifer L Y Tsang, and Claudia C dos Santos.
- aDepartment of Medicine, St Joseph's Health Centre, Toronto bDepartment of Critical Care Medicine, McMaster University, Hamilton cKeenan and Li Ka Shing Knowledge Institute of Saint Michael's Hospital dInstitute of Medical Sciences and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
- Curr Opin Crit Care. 2014 Feb 1; 20 (1): 47-55.
Purpose Of ReviewThe article provides an overview of efforts to identify and validate biomarkers in acute respiratory distress syndrome (ARDS) and a discussion of the challenges confronting researchers in this area.Recent FindingsAlthough various putative biomarkers have been investigated in ARDS, the data have been largely disappointing and the 'troponin' of ARDS remains elusive. Establishing a relationship between measurable biological processes and clinical outcomes is vital to advancing clinical trials in ARDS and expanding our arsenal of treatments for this complex syndrome.SummaryThis article summarizes the current status of ARDS biomarker research and provides a framework for future investigation.
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