• C M Mouës, F Heule, and S E R Hovius.
• Department of Plastic, Reconstructive and Hand Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands. c.moues@erasmusmc.nl
• Am. J. Surg. 2011 Apr 1;201(4):544-56.

BackgroundTopical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies.Data SourcesA database search was undertaken, and over 400 peer-reviewed articles related to the use of TNP therapy (animal, human, and in vitro studies) were identified.ConclusionsAlmost all encountered studies were related to the use of the commercial VAC device (KCI Medical, United States). Mechanisms of action that can be attributed to TNP therapy are an increase in blood flow, the promotion of angiogenesis, a reduction of wound surface area in certain types of wounds, a modulation of the inhibitory contents in wound fluid, and the induction of cell proliferation. Edema reduction and bacterial clearance, mechanisms that were attributed to TNP therapy, were not proven in basic research.Copyright © 2011 Elsevier Inc. All rights reserved.

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