• Yukiko Shimizu, Kazunori Kodama, Nobuo Nishi, Fumiyoshi Kasagi, Akihiko Suyama, Midori Soda, Eric J Grant, Hiromi Sugiyama, Ritsu Sakata, Hiroko Moriwaki, Mikiko Hayashi, Manami Konda, and Roy E Shore.
• Department of Epidemiology, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima 732-0815, Japan. shimizu@rerf.or.jp
• BMJ. 2010 Jan 1;340:b5349.

ObjectiveTo investigate the degree to which ionising radiation confers risk of mortality from heart disease and stroke.DesignProspective cohort study with more than 50 years of follow-up.SettingAtomic bomb survivors in Hiroshima and Nagasaki, Japan.Participants86 611 Life Span Study cohort members with individually estimated radiation doses from 0 to >3 Gy (86% received <0.2 Gy).Main Outcome MeasuresMortality from stroke or heart disease as the underlying cause of death and dose-response relations with atomic bomb radiation.ResultsAbout 9600 participants died of stroke and 8400 died of heart disease between 1950 and 2003. For stroke, the estimated excess relative risk per gray was 9% (95% confidence interval 1% to 17%, P=0.02) on the basis of a linear dose-response model, but an indication of possible upward curvature suggested relatively little risk at low doses. For heart disease, the estimated excess relative risk per gray was 14% (6% to 23%, P<0.001); a linear model provided the best fit, suggesting excess risk even at lower doses. However, the dose-response effect over the restricted dose range of 0 to 0.5 Gy was not significant. Prospective data on smoking, alcohol intake, education, occupation, obesity, and diabetes had almost no impact on the radiation risk estimates for either stroke or heart disease, and misdiagnosis of cancers as circulatory diseases could not account for the associations seen.ConclusionDoses above 0.5 Gy are associated with an elevated risk of both stroke and heart disease, but the degree of risk at lower doses is unclear. Stroke and heart disease together account for about one third as many radiation associated excess deaths as do cancers among atomic bomb survivors.

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