• Microbes and infection · Feb 2001

    Review

    The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation.

    • L Peiser and S Gordon.
    • Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK. Leanne.peiser@path.ox.ac.uk
    • Microbes Infect. 2001 Feb 1;3(2):149-59.

    AbstractMacrophages are able to recognise and internalise apoptotic and foreign cells from the tissue microenvironment and, where pertinent, initiate inflammation and macrophage activation. Regulation of this protective response is important so as to prevent inappropriate activation of host cells and excessive tissue damage. Scavenger receptors (SRs) are widely expressed by macrophages and are able to bind a diverse array of endogenous and foreign molecules. Studies have concentrated on the role of the receptors in atherosclerosis as they can endocytose modified lipoproteins, however, this review will detail the accumulating evidence that SRs function in innate immunity and macrophage control during inflammation.

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